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Preprints

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GENERATION OF AN INFLAMMATORY NICHE IN AN INJECTABLE HYDROGEL DEPOT THROUGH RECRUITMENT OF KEY IMMUNE CELLS IMPROVES EFFICACY OF MRNA VACCINES Meany, E.L.; Klich, J.H.; Jons, C.K.; Mao, T.; Chaudhary, N.; Utz, A.; Baillet, J.; Song, Y.E.; Saoua

GENERATION OF AN INFLAMMATORY NICHE IN AN INJECTABLE HYDROGEL DEPOT THROUGH RECRUITMENT OF KEY IMMUNE CELLS IMPROVES EFFICACY OF MRNA VACCINES

Meany, E.L.; Klich, J.H.; Jons, C.K.; Mao, T.; Chaudhary, N.; Utz, A.; Baillet, J.; Song, Y.E.; Saouaf, O.M.; Ou, B.S.; Williams, S.C.; Eckman, N.; Irvine, D.J.; Appel, E.A.*

GLASSY SURFACTANTS ENABLE ULTRA-HIGH CONCENTRATION BIOLOGIC THERAPEUTICS Jons, C.K.^; Prossnitz, A.N.^; Eckman, N.; Dong, C.; Appel, E.A.*

GLASSY SURFACTANTS ENABLE ULTRA-HIGH CONCENTRATION BIOLOGIC THERAPEUTICS

Jons, C.K.^; Prossnitz, A.N.^; Eckman, N.; Dong, C.; Appel, E.A.*

SUSTAINED VACCINE EXPOSURE ELICITS MORE RAPID, CONSISTENT, AND BROAD HUMORAL IMMUNE RESPONSES TO MULTIVALENT INFLUENZA VACCINES Saouaf, O.M.; Ou, B.S.; Song, Y.E.; Carter, J.J.; Yan, J.; Jons, C.K.; Barnes, C.O.; Appel, E.A.*

SUSTAINED VACCINE EXPOSURE ELICITS MORE RAPID, CONSISTENT, AND BROAD HUMORAL IMMUNE RESPONSES TO MULTIVALENT INFLUENZA VACCINES

Saouaf, O.M.; Ou, B.S.; Song, Y.E.; Carter, J.J.; Yan, J.; Jons, C.K.; Barnes, C.O.; Appel, E.A.*

HIGHLY EXTENSIBLE PHYSICALLY CROSSLINKED HYDROGELS FOR HIGH-SPEED 3D BIOPRINTING Song, Y.E.; Eckman, N.; Sen, S.; Jon, C.K.; Saouaf, O.M.; Appel, E.A.*

HIGHLY EXTENSIBLE PHYSICALLY CROSSLINKED HYDROGELS FOR HIGH-SPEED 3D BIOPRINTING

Song, Y.E.; Eckman, N.; Sen, S.; Jon, C.K.; Saouaf, O.M.; Appel, E.A.*

THE CHEMISTRY OF HENNA: A MODULE FOR HIGH SCHOOL STUDENTS Williams, S.C.; Appel, E.A.*

THE CHEMISTRY OF HENNA: A MODULE FOR HIGH SCHOOL STUDENTS

Williams, S.C.; Appel, E.A.*

A THIOL-ENE CLICK BASED STRATEGY TO CUSTOMIZE INJECTABLE POLYMER-NANOPARTICLE HYDROGEL PROPERTIES FOR THERAPEUTIC DELIVERY Bailey, S.J.; Eckman, N.; Brunel, E.S.; Jons, C.K.; Sen, S.; Appel, E.A.*

A THIOL-ENE CLICK BASED STRATEGY TO CUSTOMIZE INJECTABLE POLYMER-NANOPARTICLE HYDROGEL PROPERTIES FOR THERAPEUTIC DELIVERY

Bailey, S.J.; Eckman, N.; Brunel, E.S.; Jons, C.K.; Sen, S.; Appel, E.A.*

POLYACRYLAMIDE-BASED ANTIMICROBIAL POLYMERS IMMUNE TO TYPICAL RESISTANCE MECHANISMS TO REPLACE OR RESCUE ANTIBIOTICS Williams, S.C.; Chose, M.B.; Jons, C.K.; Dong, C.; Prossnitz, A.N.; Liu, X.; Lopez Hernandez, H.; Cegelski, L.; Appel, E.A.*

POLYACRYLAMIDE-BASED ANTIMICROBIAL POLYMERS IMMUNE TO TYPICAL RESISTANCE MECHANISMS TO REPLACE OR RESCUE ANTIBIOTICS

Williams, S.C.; Chose, M.B.; Jons, C.K.; Dong, C.; Prossnitz, A.N.; Liu, X.; Lopez Hernandez, H.; Cegelski, L.; Appel, E.A.*

SUSTAINED EXPOSURE TO MULTIVALENT ANTIGEN-DECORATED NANOPARTICLES GENERATES BROAD ANTI-CORONAVIRUS RESPONSES Baillet, J.; Klich, J.H.; Ou, B.S.; Meany, E.L.; Yan, J.; Bruun, T.U.J.; Utz, A.; Jons, C.K.; Lecommandoux, S.; Appel, E.A.*

SUSTAINED EXPOSURE TO MULTIVALENT ANTIGEN-DECORATED NANOPARTICLES GENERATES BROAD ANTI-CORONAVIRUS RESPONSES

Baillet, J.; Klich, J.H.; Ou, B.S.; Meany, E.L.; Yan, J.; Bruun, T.U.J.; Utz, A.; Jons, C.K.; Lecommandoux, S.; Appel, E.A.*

2024

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SAPONIN NANOPARTICLE ADJUVANTS INCORPORATING TOLL-LIKE RECEPTOR AGONISTS IMPROVE VACCINE IMMUNOMODULATION Ou, B.S.^; Baillet, J.^; Filsinger Interrante, M.V.; Adamska, J.S.; Zhou, X.; Saouaf, O.A.; Yan, J.; Klich, J.H.; Jons, C.K.; Meany, E.L.;

SAPONIN NANOPARTICLE ADJUVANTS INCORPORATING TOLL-LIKE RECEPTOR AGONISTS IMPROVE VACCINE IMMUNOMODULATION

Ou, B.S.^; Baillet, J.^; Filsinger Interrante, M.V.; Adamska, J.S.; Zhou, X.; Saouaf, O.A.; Yan, J.; Klich, J.H.; Jons, C.K.; Meany, E.L.; Valdez, A.; Carter, L.; Pulendran, B.; King, N.P.; Appel, E.A.* Science Advances (2024) PDF

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WATER-ENHANCING GELS EXHIBITING HEAT-ACTIVATED FORMATION OF SILICA AEROGELS FOR PROTECTION OF CRITICAL INFRASTRUCTURE DURING CATASTROPHIC WILDFIRE Dong, C.; d'Aquino, A.I.; Sen, S.; Hall, I.A.; Yu, A.C.; Acosta, J.D.; Appel, E.A.* Advanced Mat

WATER-ENHANCING GELS EXHIBITING HEAT-ACTIVATED FORMATION OF SILICA AEROGELS FOR PROTECTION OF CRITICAL INFRASTRUCTURE DURING CATASTROPHIC WILDFIRE

Dong, C.; d'Aquino, A.I.; Sen, S.; Hall, I.A.; Yu, A.C.; Acosta, J.D.; Appel, E.A.* Advanced Materials (2024) PDF

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NANOPARTICLE-CONJUGATED TLR9 AGONISTS IMPROVE THE POTENCY, DURABILITY, AND BREADTH OF COVID-19 VACCINES Ou, B.S.^; Baillet, J.^; Picece, V.C.T.M.^; Gale, E.C.; Powell, A.E.; Saouaf, O.M.; Yan, J.; Nejatfard, A.; Lopez Hernandez, H.; Appel, E.A.

NANOPARTICLE-CONJUGATED TLR9 AGONISTS IMPROVE THE POTENCY, DURABILITY, AND BREADTH OF COVID-19 VACCINES

Ou, B.S.^; Baillet, J.^; Picece, V.C.T.M.^; Gale, E.C.; Powell, A.E.; Saouaf, O.M.; Yan, J.; Nejatfard, A.; Lopez Hernandez, H.; Appel, E.A.* ACS Nano (2024) PDF

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BIOMATERIALS TO ENHANCE ADOPTIVE CELL THERAPY Eckman, N.^; Nejatfard, A.^; Cavet, R.; Grosskopf, A.K.*; Appel, E.A.* Nature Reviews Bioengineering (2024) PDF

BIOMATERIALS TO ENHANCE ADOPTIVE CELL THERAPY

Eckman, N.^; Nejatfard, A.^; Cavet, R.; Grosskopf, A.K.*; Appel, E.A.* Nature Reviews Bioengineering (2024) PDF

A cGAMP-CONTAINING HYDROGEL FOR PROLONGED SARS-COV-2 RBD SUBUNIT VACCINE EXPOSURE INDUCES A BROAD AND POTENT HUMORAL RESPONSE Bohnert, V.^; Gale, E.C.^; Lahey, L.J.^; Yan, J.; Powell, A.E.; Ou, B.S.; Carozza, J.A.; Li, L.*; Appel, E.A.* Advanc

A cGAMP-CONTAINING HYDROGEL FOR PROLONGED SARS-COV-2 RBD SUBUNIT VACCINE EXPOSURE INDUCES A BROAD AND POTENT HUMORAL RESPONSE

Bohnert, V.^; Gale, E.C.^; Lahey, L.J.^; Yan, J.; Powell, A.E.; Ou, B.S.; Carozza, J.A.; Li, L.*; Appel, E.A.* Advanced NanoBiomed Research (2024) PDF

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DEFINING STRUCTURE-FUNCTION RELATIONSHIPS OF AMPHIPHILIC EXCIPIENTS ENABLES RATIONAL DESIGN OF ULTRA-STABLE BIOPHARMACEUTICALS Prossnitz, A.N.; Nguyen, L.T.; Eckman, N.; Borker, S.; Tetef, S.; Autzen, A.A.A.; Fuller, G.G.; Appel, E.A.* Advance

DEFINING STRUCTURE-FUNCTION RELATIONSHIPS OF AMPHIPHILIC EXCIPIENTS ENABLES RATIONAL DESIGN OF ULTRA-STABLE BIOPHARMACEUTICALS

Prossnitz, A.N.; Nguyen, L.T.; Eckman, N.; Borker, S.; Tetef, S.; Autzen, A.A.A.; Fuller, G.G.; Appel, E.A.* Advanced Science (2024) PDF

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BIOMIMETIC NON-ERGODIC AGING BY DYNAMIC-TO-COVALENT TRANSITIONS IN PHYSICAL HYDROGELS Sen, S.; Dong, C.; d’Aquino, A.I.; Yu, A.C.; Appel, E.A.* ACS Applied Materials & Interfaces (2024) PDF Check out the Arxiv preprint of this

BIOMIMETIC NON-ERGODIC AGING BY DYNAMIC-TO-COVALENT TRANSITIONS IN PHYSICAL HYDROGELS

Sen, S.; Dong, C.; d’Aquino, A.I.; Yu, A.C.; Appel, E.A.* ACS Applied Materials & Interfaces (2024) PDF

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ELECTROCHEMICALLY MUTABLE SOFT METASURFACES Doshi, S.; Ji, A.; Mahdi, A.I.; Keene, S.T.; Selvin, S.; Lalanne, P.; Appel, E.A.; Melosh, N.A.*; Brongersma, M.L.* Nature Materials (2024) PDF

ELECTROCHEMICALLY MUTABLE SOFT METASURFACES

Doshi, S.; Ji, A.; Mahdi, A.I.; Keene, S.T.; Selvin, S.; Lalanne, P.; Appel, E.A.; Melosh, N.A.*; Brongersma, M.L.* Nature Materials (2024) PDF

DYNAMIC HYDROGEL CROSSLINK STRENGTH CONTROLS YIELDING CHARACTERISTICS AND CELL VIABILITY DURING INJECTION Eckman, N.; Grosskopf, A.K.; Jiang, G.; Kamani, K.; Huang, M.S.; Schmittlein, B.; Heilshorn, S.C.; Rogers, S.; Appel, E.A.* Biomaterials

DYNAMIC HYDROGEL CROSSLINK STRENGTH CONTROLS YIELDING CHARACTERISTICS AND CELL VIABILITY DURING INJECTION

Eckman, N.; Grosskopf, A.K.; Jiang, G.; Kamani, K.; Huang, M.S.; Schmittlein, B.; Heilshorn, S.C.; Rogers, S.; Appel, E.A.* Biomaterials Science (2024) PDF

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VIRAL VECTOR ELUTING LENSES FOR SINGLE-STEP TARGETED EXPRESSION OF GENETICALLY-ENCODED ACTIVITY SENSORS FOR IN VIVO MICROENDOSCOPIC CALCIUM IMAGING Jons, C; Cheng, D.; Dong, C.; Meany, E.; Nassi, J.*; Appel, E.A.* Macromolecular Biosciences (

VIRAL VECTOR ELUTING LENSES FOR SINGLE-STEP TARGETED EXPRESSION OF GENETICALLY-ENCODED ACTIVITY SENSORS FOR IN VIVO MICROENDOSCOPIC CALCIUM IMAGING

Jons, C; Cheng, D.; Dong, C.; Meany, E.; Nassi, J.*; Appel, E.A.* Macromolecular Biosciences (2024) PDF

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LABEL-FREE COMPOSITION ANALYSIS OF SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS BY REVERSED-PHASE LIQUID CHROMATOGRAPHY COUPLED WITH A CHARGED AEROSOL DETECTOR Tang, S.^; Pederson, Z.^; Meany, E.L.; Yen, C.-W.; Swansiger, A.K.; Prell, J.S

LABEL-FREE COMPOSITION ANALYSIS OF SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS BY REVERSED-PHASE LIQUID CHROMATOGRAPHY COUPLED WITH A CHARGED AEROSOL DETECTOR

Tang, S.^; Pederson, Z.^; Meany, E.L.; Yen, C.-W.; Swansiger, A.K.; Prell, J.S.; Chen, B.; Grosskopf, A.K.; Eckman, N.; Jiang, G.; Baillet, J.; Pellett, J.D.; Appel, E.A.* Analytical Chem (2024) PDF

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COMPOSITE GELS DESIGNED TO STICK TO BIOLOGICAL TISSUES Bailey, S.J.; Appel, E.A.* Nature (2024) PDF Check out the original article in Nature Chem Eng by Prof. Bozhi Tian and coworkers.

COMPOSITE GELS DESIGNED TO STICK TO BIOLOGICAL TISSUES

Bailey, S.J.; Appel, E.A.* Nature (2024) PDF

Check out the original article in Nature Chem Eng by Prof. Bozhi Tian and coworkers.

CLONALLY EXPANDED TARGETABLE NATURAL KILLER-LIKE NKG7 T CELLS SEED THE AGED SPINAL CORD TO DISRUPT MYELOID-DEPENDENT WOUND HEALING Kong, G.; Zhou, L.; Song, Y.; Yan, Y.; Calderazzo, S.M.; Saddala, M.S.; De Labastida Rivera, F.; Cherry, J.; Eckman

CLONALLY EXPANDED TARGETABLE NATURAL KILLER-LIKE NKG7 T CELLS SEED THE AGED SPINAL CORD TO DISRUPT MYELOID-DEPENDENT WOUND HEALING

Kong, G.; Zhou, L.; Song, Y.; Yan, Y.; Calderazzo, S.M.; Saddala, M.S.; De Labastida Rivera, F.; Cherry, J.; Eckman, N.; Appel, E.A.; Velenosi, A.; Swarup, V.; Kawaguchi, R.; Ng, S.S.; Kwon, B.; Gate, D.; Geschwind, D.; Engwerda, C.; Di Giovanni, S.* Neuron (2024) PDF

2023

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SUSTAINED DELIVERY OF GLP-1 RECEPTOR AGONISTS FROM INJECTABLE BIOMIMETIC HYDROGELS IMPROVES TREATMENT OF DIABETES d’Aquino, A.I.; Maikawa, C.L.; Nguyen, L.T.; Lu, K.; Hall, I.A.; Prossnitz, A.N.; Chang, E.; Baker, S.W.; Kasse, C.I.; Jons, C.K.;

SUSTAINED DELIVERY OF GLP-1 RECEPTOR AGONISTS FROM INJECTABLE BIOMIMETIC HYDROGELS IMPROVES TREATMENT OF DIABETES

d’Aquino, A.I.; Maikawa, C.L.; Nguyen, L.T.; Lu, K.; Hall, I.A.; Prossnitz, A.N.; Chang, E.; Baker, S.W.; Kasse, C.I.; Jons, C.K.; Yan, J.; Hovgaard, L.; Steensgaard, D.B.; Andersen, H.B.; Simonsen, L.; Appel, E.A.* Cell Reports Medicine (2023) PDF

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BROAD AND DURABLE HUMORAL RESPONSES FOLLOWING SINGLE HYDROGEL IMMUNIZATION OF SARS-COV-2 SUBUNIT VACCINES Ou, B.S.; Saouaf, O.M.; Yan, J.; Bruun, T.U.J.; Baillet, J.; King, N.P.; Appel, E.A.* Advanced Healthcare Materials (2023) PDF Chec

BROAD AND DURABLE HUMORAL RESPONSES FOLLOWING SINGLE HYDROGEL IMMUNIZATION OF SARS-COV-2 SUBUNIT VACCINES

Ou, B.S.; Saouaf, O.M.; Yan, J.; Bruun, T.U.J.; Baillet, J.; King, N.P.; Appel, E.A.* Advanced Healthcare Materials (2023) PDF

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A REGIMEN COMPRESSION STRATEGY FOR COMMERCIAL VACCINES LEVERAGING AN INJECTABLE HYDROGEL DEPOT TECHNOLOGY FOR SUSTAINED VACCINE EXPOSURE Yan, J.; Ou, B.S.; Saouaf, O.M.; Meany, E.L.; Eckman, N.; Appel, E.A.* Advanced Therapeutics (2023) PDF

A REGIMEN COMPRESSION STRATEGY FOR COMMERCIAL VACCINES LEVERAGING AN INJECTABLE HYDROGEL DEPOT TECHNOLOGY FOR SUSTAINED VACCINE EXPOSURE

Yan, J.; Ou, B.S.; Saouaf, O.M.; Meany, E.L.; Eckman, N.; Appel, E.A.* Advanced Therapeutics (2023) PDF

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SUBCUTANEOUS DELIVERY OF AN ANTIBODY AGAINST SARS-COV-2 FROM A SUPRAMOLECULAR HYDROGEL DEPOT Kasse, C.M.; Yu, A.C.; Powell, A.C.; Roth, G.A.; Liong, C.S.; Jons, C.K.; Buahin, A.; Maikawa, C.L.; Youssef, S.; Glanville, J.E.; Appel, E.A.* Biomat

SUBCUTANEOUS DELIVERY OF AN ANTIBODY AGAINST SARS-COV-2 FROM A SUPRAMOLECULAR HYDROGEL DEPOT

Kasse, C.M.; Yu, A.C.; Powell, A.C.; Roth, G.A.; Liong, C.S.; Jons, C.K.; Buahin, A.; Maikawa, C.L.; Youssef, S.; Glanville, J.E.; Appel, E.A.* Biomaterials Science (2023) PDF

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POLYACRYLAMIDE-BASED HYDROGEL COATINGS IMPROVE BIOCOMPATIBILITY OF IMPLANTED PUMP DEVICES Chan, D.; Maikawa, C.L.; d’Aquino, A.I.; Raghavan, S.S.; Troxell, M.L.; Appel, E.A.* J. Biomed. Mater. Res. Part A. (2023) PDF Check out the BioR

POLYACRYLAMIDE-BASED HYDROGEL COATINGS IMPROVE BIOCOMPATIBILITY OF IMPLANTED PUMP DEVICES

Chan, D.; Maikawa, C.L.; d’Aquino, A.I.; Raghavan, S.S.; Troxell, M.L.; Appel, E.A.* J. Biomed. Mater. Res. Part A. (2023) PDF

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MICROFLUIDIC ENCAPSULATION OF PHOTOSYNTHETIC CYANOBACTERIA IN HYDROGEL MICROPARTICLES AUGMENTS OXYGEN DELIVERY TO RESCUE ISCHEMIC MYOCARDIUM Stapleton, L.M.; Farry, J.M.; Zhu, Y.; Lucian, H.J.; Wang, H.; Paulsen, M.J.; Totherow, K.P.; Roth, G.A

MICROFLUIDIC ENCAPSULATION OF PHOTOSYNTHETIC CYANOBACTERIA IN HYDROGEL MICROPARTICLES AUGMENTS OXYGEN DELIVERY TO RESCUE ISCHEMIC MYOCARDIUM

Stapleton, L.M.; Farry, J.M.; Zhu, Y.; Lucian, H.J.; Wang, H.; Paulsen, M.J.; Totherow, K.P.; Roth, G.A.; Brower, K.K.; Fordyce, P.M.; Appel, E.A.; Woo, Y.J.* J. Biosci. Bioeng. (2023) PDF

INJECTABLE HYDROGELS FOR IMMUNE MODULATION Saouaf, O.M.; d’Aquino, A.I.; Grosskopf, A.K; Appel, E.A.* Biomedical Nanotechnology: Methods and Protocols (2023)

INJECTABLE HYDROGELS FOR IMMUNE MODULATION

Saouaf, O.M.; d’Aquino, A.I.; Grosskopf, A.K; Appel, E.A.* Biomedical Nanotechnology: Methods and Protocols (2023)

ANGIOGENIC STEM CELL DELIVERY PLATFORM TO AUGMENT POST-INFARCTION NEOVASCULATURE AND REVERSE VENTRICULAR REMODELING Shin, H.S.; Thakore, A.; Tada, Y.; Pedroza, A.J.; Ikeda, G.; Chen, I.C.; Chan, D.; Jaatinen, K.J.; Yajima, S.; Pfrender, E.M.; K

ANGIOGENIC STEM CELL DELIVERY PLATFORM TO AUGMENT POST-INFARCTION NEOVASCULATURE AND REVERSE VENTRICULAR REMODELING

Shin, H.S.; Thakore, A.; Tada, Y.; Pedroza, A.J.; Ikeda, G.; Chen, I.C.; Chan, D.; Jaatinen, K.J.; Yajima, S.; Pfrender, E.M.; Kawamura, M.; Yang, P.C.; Wu, J.C.; Appel, E.A.; Fischbein, M.P.; Woo, Y.J.; Shudo, Y.* Scientific Reports (2023) PDF

2022

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DELIVERY OF CAR-T CELLS IN A TRANSIENT INJECTABLE STIMULATORY NICHE IMPROVES TREATMENT OF SOLID TUMORS Grosskopf, A.K.^; Labanieh, L.^; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.;

DELIVERY OF CAR-T CELLS IN A TRANSIENT INJECTABLE STIMULATORY NICHE IMPROVES TREATMENT OF SOLID TUMORS

Grosskopf, A.K.^; Labanieh, L.^; Klysz, D.D.; Roth, G.A.; Xu, P.; Adebowale, O.; Gale, E.C.; Jons, C.K.; Klich, J.H.; Yan, J.; Maikawa, C.L.; Correa, S.; Ou, B.S.; d’Aquino, A.I.; Cochran, J.R.; Chaudhuri, O.; Mackall, C.L.*; Appel, E.A.* Science Advances (2022) PDF

Check out the Stanford News coverage of this work

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DESIGNING SPATIAL AND TEMPORAL CONTROL OF VACCINE RESPONSES Roth, G.A.; Picece, V.T.M.; Ou, B.S.; Luo, W.; Pulendran, B.; Appel, E.A.* Nature Reviews Materials (2022) PDF

DESIGNING SPATIAL AND TEMPORAL CONTROL OF VACCINE RESPONSES

Roth, G.A.; Picece, V.T.M.; Ou, B.S.; Luo, W.; Pulendran, B.; Appel, E.A.* Nature Reviews Materials (2022) PDF

INJECTABLE LIPOSOME BASED SUPRAMOLECULAR HYDROGELS FOR THE PROGRAMMABLE RELEASE OF MULTIPLE PROTEIN DRUGS Correa, S.^; Grosskopf, A.K.^; Klich, J.H.; Lopez Hernandez, H.; Appel, E.A.* Matter - Cell Press (2022) PDF Check out the Bio

INJECTABLE LIPOSOME BASED SUPRAMOLECULAR HYDROGELS FOR THE PROGRAMMABLE RELEASE OF MULTIPLE PROTEIN DRUGS

Correa, S.^; Grosskopf, A.K.^; Klich, J.H.; Lopez Hernandez, H.; Appel, E.A.* Matter - Cell Press (2022) PDF

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COMBINATORIAL POLYACRYLAMIDE HYDROGELS FOR PREVENTING BIOFOULING ON IMPLANTABLE BIOSENSORS Chan, D.^; Chien, J.-C.^; Axpe, E.; Blankemeier, L.; Baker, S.W.; Swaminathan, S.; Piunova, V.A.; Zubarev, D.Y.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.

COMBINATORIAL POLYACRYLAMIDE HYDROGELS FOR PREVENTING BIOFOULING ON IMPLANTABLE BIOSENSORS

Chan, D.^; Chien, J.-C.^; Axpe, E.; Blankemeier, L.; Baker, S.W.; Swaminathan, S.; Piunova, V.A.; Zubarev, D.Y.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.L.; Soh, H.T.*; Appel, E.A.* Advanced Materials (2022) PDF

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YIELD-STRESS AND CREEP CONTROL DEPOT FORMATION AND PERSISTENCE OF INJECTABLE HYDROGELS FOLLOWING SUBCUTANEOUS ADMINISTRATION Jons, C.K.; Grosskopf, A.K.; Baillet, J.; Yan, J.; Klich, J.H.; Appel, E.A.* Advanced Functional Materials (2022) P

YIELD-STRESS AND CREEP CONTROL DEPOT FORMATION AND PERSISTENCE OF INJECTABLE HYDROGELS FOLLOWING SUBCUTANEOUS ADMINISTRATION

Jons, C.K.; Grosskopf, A.K.; Baillet, J.; Yan, J.; Klich, J.H.; Appel, E.A.* Advanced Functional Materials (2022) PDF

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INJECTABLE NANOPARTICLE-BASED HYDROGELS ENABLE THE SAFE AND EFFECTIVE DEPLOYMENT OF IMMUNOSTIMULATORY CD40 AGONIST ANTIBODIES Correa, S.; Meany, E.L.; Gale, E.C.; Klich, J.H.; Saouaf, O.M.; Mayer, A.T.; Xian, Z.; Liong, C.; Brown, R.A.; Maikawa

INJECTABLE NANOPARTICLE-BASED HYDROGELS ENABLE THE SAFE AND EFFECTIVE DEPLOYMENT OF IMMUNOSTIMULATORY CD40 AGONIST ANTIBODIES

Correa, S.; Meany, E.L.; Gale, E.C.; Klich, J.H.; Saouaf, O.M.; Mayer, A.T.; Xian, Z.; Liong, C.; Brown, R.A.; Maikawa, C.L.; Grosskopf, A.K.; Mann, J.L.; Idoyaga, J.; Appel, E.A.* Advanced Science (2022) PDF

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REAL-TIME MONITORING OF DRUG PHARMACOKINETICS WITHIN TUMOR TISSUE IN LIVE ANIMALS Seo, J.-W.^; Fu, K.^; Correa, S.; Eisenstein, M.; Appel, E.A.* ; Soh, H.T.* Science Advances (2022) PDF Check out the bioRxiv preprint of this w

REAL-TIME MONITORING OF DRUG PHARMACOKINETICS WITHIN TUMOR TISSUE IN LIVE ANIMALS

Seo, J.-W.^; Fu, K.^; Correa, S.; Eisenstein, M.; Appel, E.A.*; Soh, H.T.* Science Advances (2022) PDF

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EXTREME EXTENSIBILITY IN PHYSICALLY CROSSLINKED NANOCOMPOSITE HYDROGELS LEVERAGING DYNAMIC POLYMER-NANOPARTICLE INTERACTIONS Grosskopf, A.K.; Mann, J.L; Baillet, J.; Lopez Hernandez, H.; Autzen, A.A.A.; Yu, A.C.; Appel, E.A.* Macromolecules (

EXTREME EXTENSIBILITY IN PHYSICALLY CROSSLINKED NANOCOMPOSITE HYDROGELS LEVERAGING DYNAMIC POLYMER-NANOPARTICLE INTERACTIONS

Grosskopf, A.K.; Mann, J.L; Baillet, J.; Lopez Hernandez, H.; Autzen, A.A.A.; Yu, A.C.; Appel, E.A.* Macromolecules (2022) PDF

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SUSTAINED DELIVERY APPROACHES TO IMPROVING ADAPTIVE IMMUNE RESPONSES Ou, B.S.^; Saouaf, O.M.^; Baillet, J.; Appel, E.A.* Advanced Drug Delivery Reviews (2022) PDF

SUSTAINED DELIVERY APPROACHES TO IMPROVING ADAPTIVE IMMUNE RESPONSES

Ou, B.S.^; Saouaf, O.M.^; Baillet, J.; Appel, E.A.* Advanced Drug Delivery Reviews (2022) PDF

INJECTABLE POLYMER-NANOPARTICLE HYDROGEL FOR THE SUSTAINED INTRAVITREAL DELIVERY OF BIMATOPROST Meany, E.L.^; Andaya, R.^; Tang, S.; Kasse, C.M.; Fuji, R.N.; Grosskopf, A.K.; d’Aquino, A.I.; Bartoe, J.T.; Ybarra, R.; Shelton, A.; Pederson, Z.;

INJECTABLE POLYMER-NANOPARTICLE HYDROGEL FOR THE SUSTAINED INTRAVITREAL DELIVERY OF BIMATOPROST

Meany, E.L.^; Andaya, R.^; Tang, S.; Kasse, C.M.; Fuji, R.N.; Grosskopf, A.K.; d’Aquino, A.I.; Bartoe, J.T.; Ybarra, R.; Shelton, A.; Pederson, Z.; Hu, C.; Leung, D.; Nagapudi, K.; Ubhayakar, S.; Yen, C.W.*; Appel, E.A.* Advanced Therapeutics (2022) PDF

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STABLE HIGH-CONCENTRATION MONOCLONAL ANTIBODY FORMULATIONS ENABLED BY AN AMPHIPHILIC COPOLYMER EXCIPIENT Klich, J.H.^; Kasse, C.M.^; Mann, J.L.; Huang, Y.; d’Aquino, A.I.; Grosskopf, A.K.; Baillet, J.; Fuller, G.G.; Appel, E.A.* Advanced Thera

STABLE HIGH-CONCENTRATION MONOCLONAL ANTIBODY FORMULATIONS ENABLED BY AN AMPHIPHILIC COPOLYMER EXCIPIENT

Klich, J.H.^; Kasse, C.M.^; Mann, J.L.; Huang, Y.; d’Aquino, A.I.; Grosskopf, A.K.; Baillet, J.; Fuller, G.G.; Appel, E.A.* Advanced Therapeutics (2022) PDF

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FORMULATION EXCIPIENTS AND THEIR ROLE IN INSULIN STABILITY AND ASSOCIATION STATE IN FORMULATION Maikawa, C.L.; Nguyen, L.T.; Mann, J.L.; Appel, E.A.* Pharmaceutical Research (2022) PDF

FORMULATION EXCIPIENTS AND THEIR ROLE IN INSULIN STABILITY AND ASSOCIATION STATE IN FORMULATION

Maikawa, C.L.; Nguyen, L.T.; Mann, J.L.; Appel, E.A.* Pharmaceutical Research (2022) PDF

MULTIMERIZATION OF EBOLA GPMUCIN ON PROTEIN NANOPARTICLE VACCINES HAS MINIMAL EFFECT ON ELICITATION OF NEUTRALIZING ANTIBODIES Powell, A.E.; Xu, D.; Roth, G.A.; Zhang, K.; Chiu, W.; Appel, E.A.; Kim, P.S.* Frontiers in Immunology (2022) PDF

MULTIMERIZATION OF EBOLA GPMUCIN ON PROTEIN NANOPARTICLE VACCINES HAS MINIMAL EFFECT ON ELICITATION OF NEUTRALIZING ANTIBODIES

Powell, A.E.; Xu, D.; Roth, G.A.; Zhang, K.; Chiu, W.; Appel, E.A.; Kim, P.S.* Frontiers in Immunology (2022) PDF

PNP HYDROGEL PREVENTS SYMBLEPHARA FORMATION IN MICE AFTER OCULAR ALKALI INJURY Swarup, A.; Grosskopf, A.K.; Stapleton, L.M.; Subramanium, V.R.; Li, B.; Weissman, I.L.; Appel, E.A.; Wu, A.Y.* Translational Vision Science & Technology (2022

PNP HYDROGEL PREVENTS SYMBLEPHARA FORMATION IN MICE AFTER OCULAR ALKALI INJURY

Swarup, A.; Grosskopf, A.K.; Stapleton, L.M.; Subramanium, V.R.; Li, B.; Weissman, I.L.; Appel, E.A.; Wu, A.Y.* Translational Vision Science & Technology (2022) PDF

THE LIVING INTERFACE BETWEEN SYNTHETIC BIOLOGY AND BIOMATERIAL DESIGN Liu, A.P.*; Appel, E.A.; Ashby, P.D.; Baker, B.M.; Franco, E.; Gu, L.; Haynes, K.; Joshi, N.S.; Kloxin, A.M.; Kouwer, P.H.J.; Mittal, J.; Morsut, L.; Noireaux, V.; Parekh, S.

THE LIVING INTERFACE BETWEEN SYNTHETIC BIOLOGY AND BIOMATERIAL DESIGN

Liu, A.P.*; Appel, E.A.; Ashby, P.D.; Baker, B.M.; Franco, E.; Gu, L.; Haynes, K.; Joshi, N.S.; Kloxin, A.M.; Kouwer, P.H.J.; Mittal, J.; Morsut, L.; Noireaux, V.; Parekh, S.; Schulman, R.; Tang, S.K.Y.; Valentine, M.T.; Vega, S.L.; Weber, W.; Stephanopoulos, N.; Chaudhuri, O.* Nature Materials (2022) PDF

2021

Featured
TRANSLATIONAL APPLICATIONS OF HYDROGELS Correa, S.; Grosskopf, A.K.; Lopez Hernandez, H.; Chan, D.; Yu, A.C.; Stapleton, L.M.; Appel, E.A.* Chemical Reviews (2021) PDF

TRANSLATIONAL APPLICATIONS OF HYDROGELS

Correa, S.; Grosskopf, A.K.; Lopez Hernandez, H.; Chan, D.; Yu, A.C.; Stapleton, L.M.; Appel, E.A.* Chemical Reviews (2021) PDF

HYDROGEL-BASED SLOW RELEASE OF A RECEPTOR-BINDING DOMAIN SUBUNIT VACCINE ELICITS NEUTRALIZING ANTIBODY RESPONSES AGAINST SARS-COV-2 Gale, E.C.; Powell, A.E.; Roth, G.A.; Ou, B.S.; Meany, E.L.; Grosskopf, A.K.; Adamska, J.; Picece, V.C.T.M.; d’A

HYDROGEL-BASED SLOW RELEASE OF A RECEPTOR-BINDING DOMAIN SUBUNIT VACCINE ELICITS NEUTRALIZING ANTIBODY RESPONSES AGAINST SARS-COV-2

Gale, E.C.; Powell, A.E.; Roth, G.A.; Ou, B.S.; Meany, E.L.; Grosskopf, A.K.; Adamska, J.; Picece, V.C.T.M.; d’Aquino, A.I.; Pulendran, B.; Kim, P.S.; Appel, E.A.* Advanced Materials (2021) PDF

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ENGINEERING BIOPHARMACEUTICAL FORMULATIONS TO IMPROVE DIABETES MANAGEMENT Maikawa, C.L.; d’Aquino, A.I.; Lal, R.A.; Buckingham, B.A.; Appel, E.A.* Science Translational Medicine (2021) PDF

ENGINEERING BIOPHARMACEUTICAL FORMULATIONS TO IMPROVE DIABETES MANAGEMENT

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PHYSICAL NETWORKS FROM ENTROPY-DRIVEN NON-COVALENT INTERACTIONS Yu, A.C.; Lian, H.; Kong, X.; Lopez Hernandez, H.; Qin, J.; Appel, E.A.* Nature Communications (2021) PDF Check out the Stanford News coverage

PHYSICAL NETWORKS FROM ENTROPY-DRIVEN NON-COVALENT INTERACTIONS

Yu, A.C.; Lian, H.; Kong, X.; Lopez Hernandez, H.; Qin, J.; Appel, E.A.* Nature Communications (2021) PDF

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CONSISTENT TUMORIGENESIS WITH SELF-ASSEMBLED HYDROGELS ENABLES HIGH-POWERED MURINE CANCER STUDIES Grosskopf, A.K.; Correa, S.; Baillet, J.; Maikawa, C.L.; Gale, E.C.; Brown, R.A.; Appel, E.A.* Communications Biology (2021) PDF Check out

CONSISTENT TUMORIGENESIS WITH SELF-ASSEMBLED HYDROGELS ENABLES HIGH-POWERED MURINE CANCER STUDIES

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ULTRA-FAST INSULIN-PRAMLINTIDE CO-FORMULATION FOR IMPROVED GLUCOSE MANAGEMENT IN DIABETIC RATS Maikawa, C.L.; Chen, P.C.; Vuong, E.T.; Nguyen, L.T.; Mann, J.L.; d’Aquino, A.I.; Lal, R.A.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Advanced Sc

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Maikawa, C.L.; Chen, P.C.; Vuong, E.T.; Nguyen, L.T.; Mann, J.L.; d’Aquino, A.I.; Lal, R.A.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Advanced Science (2021) PDF

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PROLONGED CODELIVERY OF HEMAGGLUTININ AND A TLR7/8 AGONIST IN A SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGEL ENHANCES POTENCY AND BREADTH OF INFLUENZA VACCINATION Roth, G.A.^; Saouaf, O.M.^; Smith, A.A.A.; Gale, E.C.; Alcantara Hernandez, M.; I

PROLONGED CODELIVERY OF HEMAGGLUTININ AND A TLR7/8 AGONIST IN A SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGEL ENHANCES POTENCY AND BREADTH OF INFLUENZA VACCINATION

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This article was featured in the Nanomedicine Advances in Infectious Disease special issue

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Saouaf, O.M.; Roth, G.A.; Ou, B.; Smith, A.A.A.; Yu, A.C.; Gale, E.C.; Grosskopf, A.K.; Picece, V.C.T.M.; Appel, E.A.* Journal of Biomedical Materials Research: Part A (2021) PDF

DYNAMIC HYDROGELS FOR PREVENTION OF POST-OPERATIVE PERITONEAL ADHESIONS Stapleton, L.M.; Lucian, H.J.; Grosskopf, A.K.; Smith, A.A.A.; Totherow, K.P.; Woo, Y.J.*; Appel, E.A.* Advanced Therapeutics (2021) PDF Check out the Advanced Sc

DYNAMIC HYDROGELS FOR PREVENTION OF POST-OPERATIVE PERITONEAL ADHESIONS

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ENGINEERING INSULIN COLD CHAIN RESILIENCE TO IMPROVE GLOBAL ACCESS Maikawa, C.L.^; Mann, J.L.^; Kannan, A.; Meis, C.M.; Ou, B.S.; Smith, A.A.A.; Fuller, G.G.; Maahs, D.M.; Appel, E.A.* Biomacromolecules PDF Check out the BioRxiv

ENGINEERING INSULIN COLD CHAIN RESILIENCE TO IMPROVE GLOBAL ACCESS

Maikawa, C.L.^; Mann, J.L.^; Kannan, A.; Meis, C.M.; Ou, B.S.; Smith, A.A.A.; Fuller, G.G.; Maahs, D.M.; Appel, E.A.* Biomacromolecules PDF

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GELATION AND YIELDING BEHAVIOR OF POLYMER-NANOPARTICLE HYDROGELS Grosskopf, A.K.; Saouaf, O.M.; Lopez Hernandez, H.; Appel, E.A.* Journal of Polymer Science (2021) PDF Check out the ChemRxiv preprint of this work

GELATION AND YIELDING BEHAVIOR OF POLYMER-NANOPARTICLE HYDROGELS

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ENHANCED HUMORAL IMMUNE RESPONSE BY HIGH DENSITY TLR AGONIST PRESENTATION ON HYPERBRANCHED POLYMERS Liong, C.S.^; Smith, A.A.A.^; Mann, J.L.; Roth, G.A.; Gale, E.C.; Maikawa, C.L.; Ou, B.S.; Appel, E.A.* Advanced Therapeutics (2021) PDF

ENHANCED HUMORAL IMMUNE RESPONSE BY HIGH DENSITY TLR AGONIST PRESENTATION ON HYPERBRANCHED POLYMERS

Liong, C.S.^; Smith, A.A.A.^; Mann, J.L.; Roth, G.A.; Gale, E.C.; Maikawa, C.L.; Ou, B.S.; Appel, E.A.* Advanced Therapeutics (2021) PDF

AFFINITY-DIRECTED DYNAMICS OF HOST-GUEST MOTIFS FOR PHARMACOKINETIC MODULATION VIA SUPRAMOLECULAR PEGYLATION Maikawa, C.L.; d’Aquino, A.I.; Vuong, E.T.; Su, B.; Zou, L.; Chen, P.C.; Nguyen, L.T.; Autzen, A.A.A.; Mann, J.L.; Webber, M.J.*; App

AFFINITY-DIRECTED DYNAMICS OF HOST-GUEST MOTIFS FOR PHARMACOKINETIC MODULATION VIA SUPRAMOLECULAR PEGYLATION

Maikawa, C.L.; d’Aquino, A.I.; Vuong, E.T.; Su, B.; Zou, L.; Chen, P.C.; Nguyen, L.T.; Autzen, A.A.A.; Mann, J.L.; Webber, M.J.*; Appel, E.A.* Biomacromolecules PDF

CONTROLLING PROPERTIES OF THERMOGELS BY TUNING CRITICAL SOLUTION BEHAVIOUR OF TERNARY COPOLYMERS Smith, A.A.A.; Maikawa, C.L.; Lopez Hernandez, H.; Appel, E.A.* Polymer Chemistry (2021) PDF This article was featured in the Pioneering

CONTROLLING PROPERTIES OF THERMOGELS BY TUNING CRITICAL SOLUTION BEHAVIOUR OF TERNARY COPOLYMERS

Smith, A.A.A.; Maikawa, C.L.; Lopez Hernandez, H.; Appel, E.A.* Polymer Chemistry (2021) PDF

This article was featured in the Pioneering Investigators 2021 special collection

FULL CLOSED-LOOP OPEN-SOURCE ALGORITHM PERFORMANCE COMPARISON IN PIGS WITH DIABETES Lal, R.A.^; Maikawa, C.L.^; Lewis, D.; Baker, S.W.; Smith, A.A.A.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; L

FULL CLOSED-LOOP OPEN-SOURCE ALGORITHM PERFORMANCE COMPARISON IN PIGS WITH DIABETES

Lal, R.A.^; Maikawa, C.L.^; Lewis, D.; Baker, S.W.; Smith, A.A.A.; Roth, G.A.; Gale, E.C.; Stapleton, L.M.; Mann, J.L.; Yu, A.C.; Correa, S.; Grosskopf, A.K.; Liong, C.S.; Meis, C.M.; Chan, D.; Garner, J.P.; Maahs, D.M.; Buckingham, B.A.; Appel, E.A.* Clinical & Translational Medicine (2021) PDF

SEASONAL IMPACT OF PHOSPHATE-BASED FIRE RETARDANTS ON SOIL CHEMISTRY FOLLOWING PROPHYLACTIC TREATMENT OF VEGETATION Yu, A.C.; Reinhart, M.; Hunter, R.; Lu, K.; Maikawa, C.L.; Rajakaruna, N.; Acosta, J.D.; Stubler, C.; Appel, C.*; Appel, E.A.*

SEASONAL IMPACT OF PHOSPHATE-BASED FIRE RETARDANTS ON SOIL CHEMISTRY FOLLOWING PROPHYLACTIC TREATMENT OF VEGETATION

Yu, A.C.; Reinhart, M.; Hunter, R.; Lu, K.; Maikawa, C.L.; Rajakaruna, N.; Acosta, J.D.; Stubler, C.; Appel, C.*; Appel, E.A.* Environmental Science & Technology (2021) PDF

MORE THAN A FERTILIZER: WASTEWATER-DERIVED STRUVITE AS A HIGH VALUE, SUSTAINABLE FIRE RETARDANT Kim, A.H.; Yu, A.C.; Abbadi, S.H.E.; Lu, K.; Chan, D.; Appel, E.A.*; Criddle, C.S.* Green Chemistry (2021) PDF Check out the RSC Chemistry

MORE THAN A FERTILIZER: WASTEWATER-DERIVED STRUVITE AS A HIGH VALUE, SUSTAINABLE FIRE RETARDANT

Kim, A.H.; Yu, A.C.; Abbadi, S.H.E.; Lu, K.; Chan, D.; Appel, E.A.*; Criddle, C.S.* Green Chemistry (2021) PDF

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INJECTABLE SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS FOR CELL AND DRUG DELIVERY APPLICATIONS Meis, C.M.^; Grosskopf, A.K.^; Correa, S.; Appel, E.A.* Journal of Visualized Experiments (2021) PDF VIDEO

INJECTABLE SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS FOR CELL AND DRUG DELIVERY APPLICATIONS

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MIR-106A-363 CLUSTER IN EXTRACELLULAR VESICLES PROMOTES ENDOGENOUS MYOCARDIAL REPAIR VIA NOTCH3 PATHWAY IN ISCHEMIC HEART INJURY Jung, J.-H.; Ikeda, G.; von Bornstadt, D.; Santoso, M.R.; Wahlquist, C.; Rhee, S.; Jeon, Y.-J.; Yu, A.C.; O’brien,

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Jung, J.-H.; Ikeda, G.; von Bornstadt, D.; Santoso, M.R.; Wahlquist, C.; Rhee, S.; Jeon, Y.-J.; Yu, A.C.; O’brien, C.G.; Red-Horse, K.; Appel, E.A.; Mercola, M.; Woo, J.Y.; Yang, P.C.* Basic Research in Cardiology (2021) PDF

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ISTHMIN-1 IS AN ADIPOKINE THAT PROMOTES GLUCOSE UPDATE AND IMPROVES GLUCOSE TOLERANCE AND HEPATIC STEATOSIS

Jiang, Z.; Zhao, M.; Voilquin, L.; Jung, Y.; Aikio, M.A.; Sahai, T.; Dou, F.; Roche, A.; Carcamo-Orive, I.; Knowles, J.W.; Wabitsch, M.; Appel, E.A.; Maikawa, C.L.; Camporez, J.P.; Shulman, G.I.; Tsai, L.; Rosen, E.D.; Gardner, C.D.; Spiegelman, B.M.; Svensson, K.J.* Cell Metabolism (2021) PDF

2020

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Roth, G.A.; Gale, E.C.; Alcantara Herandez, M.; Luo, W.; Axpe, E.; Verma, R.; Yin, Q.; Yu, A.C.; Lopez Hernandez, H.; Maikawa, C.L.; Smith, A.A.A.; Davis, M.M.; Pulendran, B.; Idoyaga, I.; Appel, E.A.* ACS Central Science (2020) PDF

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LIPID NANODISCS VIA ORDERED COPOLYMERS Smith, A.A.A.^; Autzen, H.E.^; Faust, B; Mann, J.L.; Muir, B.W.; Howard, S.; Postma, A.; Spakowitz, A.J.; Cheng, Y.*; Appel, E.A.* Chem - Cell Press (2020) PDF

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Smith, A.A.A.^; Autzen, H.E.^; Faust, B; Mann, J.L.; Muir, B.W.; Howard, S.; Postma, A.; Spakowitz, A.J.; Cheng, Y.*; Appel, E.A.* Chem - Cell Press (2020) PDF

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SITE-SELECTIVE MODIFICATION OF PROTEINS USING CUCURBIT[7]URIL AS SUPRAMOLECULAR PROTECTION FOR N-TERMINAL AROMATIC AMINO ACIDS Smith, A.A.A.; Maikawa, C.L.; Roth, G.A.; Appel, E.A.* Organic & Biomolecular Chemistry (2020) PDF

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ENGINEERED BIOMATERIALS FOR HEART DISEASE

Stapleton, L.M.; Zhu, Y.; Woo, J.Y.; Appel, E.A.* Current Opinion in Biotechnology (2020) PDF

WILL THE PANDEMIC MAKE THE WEST MORE VULNERABLE TO WILDFIRES? Field, C.B.*; Appel, E.A.* New York Times (2020) PDF

WILL THE PANDEMIC MAKE THE WEST MORE VULNERABLE TO WILDFIRES?

Field, C.B.*; Appel, E.A.* New York Times (2020) PDF

MULTI-PHASE CATHETER-INJECTABLE HYDROGEL ENABLES DUAL-STAGE PROTEIN-ENGINEERED CYTOKINE RELEASE TO MITIGATE ADVERSE LEFT VENTRICULAR REMODELING FOLLOWING MYOCARDIAL INFARCTION IN A SMALL ANIMAL MODEL AND A LARGE ANIMAL MODEL Steele, A.N.; Pauls

MULTI-PHASE CATHETER-INJECTABLE HYDROGEL ENABLES DUAL-STAGE PROTEIN-ENGINEERED CYTOKINE RELEASE TO MITIGATE ADVERSE LEFT VENTRICULAR REMODELING FOLLOWING MYOCARDIAL INFARCTION IN A SMALL ANIMAL MODEL AND A LARGE ANIMAL MODEL

Steele, A.N.; Paulsen, M.J.; Wang, H.; Stapleton, L.M.; Lucian, H.J.; Eskandari, A.; Hironaka, C.E.; Farry, J.M.; Baker, S.W.; Thakore, A.D.; Jaatinen, K.J.; Tada, Y.; Hollander, M.J.; Williams, K.M.; Seymour, A.J.; Totherow, K.; Yu, A.C.; Cochran, J.R.; Appel, E.A.; Woo, Y.J.* Cytokine (2020) PDF

A HUMAN MISSION TO MARS: PREDICTING THE BONE MINERAL DENSITY LOSS OF ASTRONAUTS Axpe, E.; Chan, D.; Abegaz, M.F.; Schreurs, A.-S.; Alwood, J.S.; Globus, R.K; Appel, E.A.* PLOS One (2020) PDF Check out the Stanford News article desc

A HUMAN MISSION TO MARS: PREDICTING THE BONE MINERAL DENSITY LOSS OF ASTRONAUTS

Axpe, E.; Chan, D.; Abegaz, M.F.; Schreurs, A.-S.; Alwood, J.S.; Globus, R.K; Appel, E.A.* PLOS One (2020) PDF

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TOWARDS BRAIN-TISSUE-LIKE BIOMATERIALS Axpe, E.; Orive, G.; Franze, K.; Appel, E.A.* Nature Communications (2020) PDF

TOWARDS BRAIN-TISSUE-LIKE BIOMATERIALS

Axpe, E.; Orive, G.; Franze, K.; Appel, E.A.* Nature Communications (2020) PDF

THE COVID-19 LOCKDOWNS: A WINDOW INTO THE EARTH SYSTEM Diffenbaugh, N.S.*; Field, C.B.; Appel, E.A.; Baldocchi, D.D.; Burke, M.; Burney, J.A.; Davis, S.J.; Fiore, A.M.; Fletcher, S.M.; Hertel, T.W.; Horton, D.E.; Hsiang, S.M.; Jackson, R.B.; Ji

THE COVID-19 LOCKDOWNS: A WINDOW INTO THE EARTH SYSTEM

Diffenbaugh, N.S.*; Field, C.B.; Appel, E.A.; Baldocchi, D.D.; Burke, M.; Burney, J.A.; Davis, S.J.; Fiore, A.M.; Fletcher, S.M.; Hertel, T.W.; Horton, D.E.; Hsiang, S.M.; Jackson, R.B.; Jin, X.; Levi, M.; Lobell, D.B.; McKinley, G.A.; Moore, F.C.; Montgomery, A.; Nadeau, K.C.; Pataki, D.E.; Randerson, J.T.; Reichstein, M.; Schnell, J.L.; Seneviratne, S.L.; Singh, D.; Steiner, A.L.; Wong-Parodi, G. Nature Reviews Earth & Environment (2020) PDF

MRBLES 2.0: HIGH-THROUGHPUT GENERATION OF CHEMICALLY FUNCTIONALIZED SPECTRALLY AND MAGNETICALLY ENCODED HYDROGEL BEADS USING A SIMPLE SINGLE-LAYER MICROFLUIDIC DEVICE Feng, Y.; White, A.K.; Hein, J.B.; Appel, E.A.; Fordyce, P.M.* Microsystems

MRBLES 2.0: HIGH-THROUGHPUT GENERATION OF CHEMICALLY FUNCTIONALIZED SPECTRALLY AND MAGNETICALLY ENCODED HYDROGEL BEADS USING A SIMPLE SINGLE-LAYER MICROFLUIDIC DEVICE

Feng, Y.; White, A.K.; Hein, J.B.; Appel, E.A.; Fordyce, P.M.* Microsystems & Nanoengineering (2020) PDF

2019

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WILDFIRE PREVENTION THROUGH PROPHYLACTIC TREATMENT OF HIGH-RISK LANDSCAPES USING VISCOELASTIC RETARDANT FLUIDS Yu, A.C.; Lopez Hernandez, H.; Kim, A.H.; Stapleton, L.M.; Brand, R.J.; Mellor, E.T.; Bauer, C.P.; McCurdy, G.D.; Wolff, A.J.; Chan,

WILDFIRE PREVENTION THROUGH PROPHYLACTIC TREATMENT OF HIGH-RISK LANDSCAPES USING VISCOELASTIC RETARDANT FLUIDS

Yu, A.C.; Lopez Hernandez, H.; Kim, A.H.; Stapleton, L.M.; Brand, R.J.; Mellor, E.T.; Bauer, C.P.; McCurdy, G.D.; Wolff, A.J.; Chan, D.; Criddle, C.S.; Acosta, J.D.; Appel, E.A.* Proceedings of the National Academy of Science (2019) PDF, BURN VIDEO, ART

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USE OF A SUPRAMOLECULAR POLYMERIC HYDROGEL AS AN EFFECTIVE POST-OPERATIVE PERICARDIAL ADHESION BARRIER Stapleton, L.M.; Steele, A.N.; Wang, H.; Lopez Hernandez, H.; Yu, A.C.; Paulsen, M.J.; Smith, A.A.A.; Roth, G.A.; Thakore, A.D.; Lucian, H.J.

USE OF A SUPRAMOLECULAR POLYMERIC HYDROGEL AS AN EFFECTIVE POST-OPERATIVE PERICARDIAL ADHESION BARRIER

Stapleton, L.M.; Steele, A.N.; Wang, H.; Lopez Hernandez, H.; Yu, A.C.; Paulsen, M.J.; Smith, A.A.A.; Roth, G.A.; Thakore, A.D.; Lucian, H.J.; Totherow, K.P.; Baker, S.W.; Tada, Y.; Farry, J.M.; Eskandari, A.; Hironaka, C.E.; Jaatinen, K.J.; Williams, K.M.; Bergamasco, H.; Marschel, C.; Chadwick, B.; Grady, F.; Ma, M.; Appel, E.A.*; Woo, Y.J.* Nature Biomedical Engineering (2019) PDF, COVER ART

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Check out the Nature Bioengineering Research community coverage of this work

A NANOPARTICLE PLATFORM FOR IMPROVED POTENCY, STABILITY, AND ADJUVANTICITY OF POLY(I:C) Gale, E.C.; Roth, G.A.; Smith, A.A.A.; Alcántara-Hernández, M.; Idoyaga, J.; Appel, E.A.* Advanced Therapeutics (2019) PDF

A NANOPARTICLE PLATFORM FOR IMPROVED POTENCY, STABILITY, AND ADJUVANTICITY OF POLY(I:C)

Gale, E.C.; Roth, G.A.; Smith, A.A.A.; Alcántara-Hernández, M.; Idoyaga, J.; Appel, E.A.* Advanced Therapeutics (2019) PDF

STABLE MONOMERIC INSULIN FORMULATIONS ENABLED BY SUPRAMOLECULAR PEGYLATION OF INSULIN ANALOGUES Maikawa, C.L.^; Smith, A.A.A.^; Zou, L.; Meis, C.M.; Mann, J.L.; Webber, M.J.; Appel, E.A.* Advanced Therapeutics (2019) PDF

STABLE MONOMERIC INSULIN FORMULATIONS ENABLED BY SUPRAMOLECULAR PEGYLATION OF INSULIN ANALOGUES

Maikawa, C.L.^; Smith, A.A.A.^; Zou, L.; Meis, C.M.; Mann, J.L.; Webber, M.J.; Appel, E.A.* Advanced Therapeutics (2019) PDF

INJECTABLE SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS ENHANCE HUMAN MESENCHYMAL STEM CELL DELIVERY Grosskopf, A.K.; Roth, G.A.; Smith, A.A.A.; Gale, E.C.; Lopez Hernandez, H.; Appel, E.A.* Bioengineering & Translational Medicine (2019)

INJECTABLE SUPRAMOLECULAR POLYMER-NANOPARTICLE HYDROGELS ENHANCE HUMAN MESENCHYMAL STEM CELL DELIVERY

Grosskopf, A.K.; Roth, G.A.; Smith, A.A.A.; Gale, E.C.; Lopez Hernandez, H.; Appel, E.A.* Bioengineering & Translational Medicine (2019) PDF

A MULTI-SCALE MODEL FOR SOLUTE DIFFUSION IN HYDROGELS Axpe, E.; Chan, D.; Offeddu, G.S.; Chang, Y.; Merida, D.; Lopez Hernandez, H.; Appel, E.A.* Macromolecules (2019) PDF , CALCULATOR

A MULTI-SCALE MODEL FOR SOLUTE DIFFUSION IN HYDROGELS

Axpe, E.; Chan, D.; Offeddu, G.S.; Chang, Y.; Merida, D.; Lopez Hernandez, H.; Appel, E.A.* Macromolecules (2019) PDF, CALCULATOR

A BIOCOMPATIBLE THERAPEUTIC CATHETER-DELIVERABLE HYDROGEL FOR IN SITU TISSUE ENGINEERING Steele, A.N.; Stapleton, L.M.; Farry, J.M.; Lucian, H.J.; Paulsen, M.J.; Eskandari, A.; Hironaka, C.E.; Thakore, A.D.; Wang, H.; Yu, A.C.; Chan, D.; Appel,

A BIOCOMPATIBLE THERAPEUTIC CATHETER-DELIVERABLE HYDROGEL FOR IN SITU TISSUE ENGINEERING

Steele, A.N.; Stapleton, L.M.; Farry, J.M.; Lucian, H.J.; Paulsen, M.J.; Eskandari, A.; Hironaka, C.E.; Thakore, A.D.; Wang, H.; Yu, A.C.; Chan, D.; Appel, E.A.*; Woo, Y.J.* Advanced Healthcare Materials (2019) PDF

BLOCK COPOLYMER COMPOSITION DRIVES FUNCTION OF SELF-ASSEMBLED NANOPARTICLES FOR DELIVERY OF SMALL-MOLECULE CARGO Maikawa, C.L.; Sevit, A.; Lin, B.; Wallstrom, R.J.; Mann, J.L.; Yu, A.C.; Waymouth, R.M.; Appel, E.A.* Journal of Polymer Science:

BLOCK COPOLYMER COMPOSITION DRIVES FUNCTION OF SELF-ASSEMBLED NANOPARTICLES FOR DELIVERY OF SMALL-MOLECULE CARGO

Maikawa, C.L.; Sevit, A.; Lin, B.; Wallstrom, R.J.; Mann, J.L.; Yu, A.C.; Waymouth, R.M.; Appel, E.A.* Journal of Polymer Science: Polymer Chemistry (2019) PDF

INJECTABLE POLYMER-NANOPARTICLE HYDROGELS FOR LOCAL IMMUNE CELL RECRUITMENT Owen S. Fenton; Mark W. Tibbitt; Eric A. Appel; Siddharth Jhunjhunwala; Matthew J. Webber; Robert Langer * Biomacromolecules (2019) PDF , COVER ART

INJECTABLE POLYMER-NANOPARTICLE HYDROGELS FOR LOCAL IMMUNE CELL RECRUITMENT

Owen S. Fenton; Mark W. Tibbitt; Eric A. Appel; Siddharth Jhunjhunwala; Matthew J. Webber; Robert Langer* Biomacromolecules (2019) PDF, COVER ART

UNIVERSAL SCALING BEHAVIOR DURING NETWORK FORMATION IN CONTROLLED RADICAL POLYMERIZATIONS Mann, J.L.; Rossi, R.L.; Smith, A.A.A.; Appel, E.A.* Macromolecules (2019) PDF

UNIVERSAL SCALING BEHAVIOR DURING NETWORK FORMATION IN CONTROLLED RADICAL POLYMERIZATIONS

Mann, J.L.; Rossi, R.L.; Smith, A.A.A.; Appel, E.A.* Macromolecules (2019) PDF

2018

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NON-NEWTONIAN POLYMER-NANOPARTICLE HYDROGELS ENHANCE CELL VIABILITY DURING INJECTION Lopez Hernandez, H.; Grosskopf, A.K.; Stapleton, L.M.; Agmon, G.; Appel, E.A.* Macromolecular Bioscience (2018) PDF

NON-NEWTONIAN POLYMER-NANOPARTICLE HYDROGELS ENHANCE CELL VIABILITY DURING INJECTION

Lopez Hernandez, H.; Grosskopf, A.K.; Stapleton, L.M.; Agmon, G.; Appel, E.A.* Macromolecular Bioscience (2018) PDF

2017

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MIXED REVERSIBLE COVALENT CROSSLINK KINETICS ENABLE PRECISE, HIERARCHICAL MECHANICAL TUNING OF HYDROGEL NETWORKS Yesilyurt, V.^; Ayoob, A.M.^; Appel, E.A.; Borenstein, J.T.; Langer, R.; Anderson, D.G.*  Advanced Materials  (2017) PD

MIXED REVERSIBLE COVALENT CROSSLINK KINETICS ENABLE PRECISE, HIERARCHICAL MECHANICAL TUNING OF HYDROGEL NETWORKS

Yesilyurt, V.^; Ayoob, A.M.^; Appel, E.A.; Borenstein, J.T.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF

SINGLE-CHAIN POLYMERIC NANOCARRIERS: A PLATFORM FOR DETERMINING STRUCTURE-FUNCTION CORRELATIONS IN THE DELIVERY OF MOLECULAR CARGO Chan, D.; Yu, A.; Appel, E.A.*  Biomacromolecules  (2017) PDF

SINGLE-CHAIN POLYMERIC NANOCARRIERS: A PLATFORM FOR DETERMINING STRUCTURE-FUNCTION CORRELATIONS IN THE DELIVERY OF MOLECULAR CARGO

Chan, D.; Yu, A.; Appel, E.A.* Biomacromolecules (2017) PDF

SYNTHESIS AND BIOLOGICAL EVALUATION OF IONIZABLE LIPID MATERIALS FOR THE IN VIVO DELIVERY OF MESSENGER RNA TO B LYMPHOCYTES Fenton, O.S.; Kauffman, K.J.; Kaczmarek, J.C.; McClellan, R.L.; Jhunjhunwala, S.; Tibbitt, M.W.; Zeng, M.D.; Appel, E.A.

SYNTHESIS AND BIOLOGICAL EVALUATION OF IONIZABLE LIPID MATERIALS FOR THE IN VIVO DELIVERY OF MESSENGER RNA TO B LYMPHOCYTES

Fenton, O.S.; Kauffman, K.J.; Kaczmarek, J.C.; McClellan, R.L.; Jhunjhunwala, S.; Tibbitt, M.W.; Zeng, M.D.; Appel, E.A.; Dorkin, J.R.; Mir, F.F.; Yang, J.H.; Oberli, M.A.; Heartlein, M.W.; DeRosa, R.; Langer, R.; Anderson, D.G.* Advanced Materials (2017) PDF

DECOUPLED ASSOCIATIVE AND DISSOCIATIVE PROCESSES IN HIGHLY DYNAMIC HOST-GUEST COMPLEXES Appel, E.A.*; Biedermann, F.*; Hoogland, D.; del Barrio, J.; Driscoll, M.D.; Hay, S.; Wales, D.J.; Scherman, O.A.* Journal of the American Chemical Society

DECOUPLED ASSOCIATIVE AND DISSOCIATIVE PROCESSES IN HIGHLY DYNAMIC HOST-GUEST COMPLEXES

Appel, E.A.*; Biedermann, F.*; Hoogland, D.; del Barrio, J.; Driscoll, M.D.; Hay, S.; Wales, D.J.; Scherman, O.A.* Journal of the American Chemical Society (2017) PDF

DISTINGUISHING RELAXATION DYNAMICS IN TRANSIENTLY CROSSLINKED POLYMERIC NETWORKS Tan, C.S.Y.; Agmon, G.; Liu, J.; Hoogland, D.; Janecek, E.-R.; Appel, E.A.*; Scherman, O.A.*  Polymer Chemistry  (2017) PDF

DISTINGUISHING RELAXATION DYNAMICS IN TRANSIENTLY CROSSLINKED POLYMERIC NETWORKS

Tan, C.S.Y.; Agmon, G.; Liu, J.; Hoogland, D.; Janecek, E.-R.; Appel, E.A.*; Scherman, O.A.* Polymer Chemistry (2017) PDF

MECHANISTIC UNDERSTANDING OF IN VIVO PROTEIN CORONA FORMATION ON POLYMERIC NANOPARTICLES AND IMPACT ON PHARMACOKINETICS Bertrand, N.; Grenier, P.; Mahmoudi, M.; Lima, E.; Appel, E.A.; Dormont, F.; Lim, J.-M.; Karnik, R.;&nbs

MECHANISTIC UNDERSTANDING OF IN VIVO PROTEIN CORONA FORMATION ON POLYMERIC NANOPARTICLES AND IMPACT ON PHARMACOKINETICS

Bertrand, N.; Grenier, P.; Mahmoudi, M.; Lima, E.; Appel, E.A.; Dormont, F.; Lim, J.-M.; Karnik, R.; Langer, R.; Farokhzad, O.* Nature Communications (2017) PDF

SUPRAMOLECULAR POLYMERIC BIOMATERIALS Mann, J.L.^; Yu, A.C.^; Agmon, G.; Appel, E.A.* Biomaterials Science  (2017) PDF

SUPRAMOLECULAR POLYMERIC BIOMATERIALS

Mann, J.L.^; Yu, A.C.^; Agmon, G.; Appel, E.A.* Biomaterials Science (2017) PDF

ENGINEERING THE MECHANICAL PROPERTIES OF POLYMER NETWORKS WITH PRECISE DOPING OF PRIMARY DEFECTS Chan, D.; Ding, Y.; Dauskardt, R.H.; Appel, E.A.* ACS Applied Materials and Interfaces  (2017) PDF

ENGINEERING THE MECHANICAL PROPERTIES OF POLYMER NETWORKS WITH PRECISE DOPING OF PRIMARY DEFECTS

Chan, D.; Ding, Y.; Dauskardt, R.H.; Appel, E.A.* ACS Applied Materials and Interfaces (2017) PDF

2016

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SCALABLE MANUFACTURING OF BIOMIMETIC MOLDABLE HYDROGELS FOR INDUSTRIAL APPLICATIONS Yu, A.C.; Chen, H.; Chan, D.; Agmon, G.; Stapleton, L.M.; Sevit, A.M.; Tibbitt, M.W.; Acosta, J.D.; Zhang, T.; Franzia, P.W.; Langer, R.; Appel, E.A.*

SCALABLE MANUFACTURING OF BIOMIMETIC MOLDABLE HYDROGELS FOR INDUSTRIAL APPLICATIONS

Yu, A.C.; Chen, H.; Chan, D.; Agmon, G.; Stapleton, L.M.; Sevit, A.M.; Tibbitt, M.W.; Acosta, J.D.; Zhang, T.; Franzia, P.W.; Langer, R.; Appel, E.A.* Proceedings of the National Academy of Sciences (2016) PDF

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SUPRAMOLECULAR BIOMATERIALS Webber, M.J.^; Appel, E.A.^; Meijer, E.W.; Langer, R.*  Nature Materials  (2016) PDF

SUPRAMOLECULAR BIOMATERIALS

Webber, M.J.^; Appel, E.A.^; Meijer, E.W.; Langer, R.* Nature Materials (2016) PDF

SUPRAMOLECULAR PEGYLATION OF BIOPHARMACEUTICALS Webber, M.J.^; Appel, E.A.^; Vinciguerra, B.; Thapa, L.S.; Cortinas, A.B.; Jhunjhunwala, S.; Isaacs, L.*; Langer, R.*; Anderson, D.G.*  Proceedings of the National Academy of Sciences  (

SUPRAMOLECULAR PEGYLATION OF BIOPHARMACEUTICALS

Webber, M.J.^; Appel, E.A.^; Vinciguerra, B.; Thapa, L.S.; Cortinas, A.B.; Jhunjhunwala, S.; Isaacs, L.*; Langer, R.*; Anderson, D.G.* Proceedings of the National Academy of Sciences (2016) PDF

BIOINSPIRED ALKENYL AMINO ALCOHOL IONIZABLE LIPID MATERIALS FOR HIGHLY POTENT IN VIVO MRNA DELIVERY Fenton, O.S.; Kauffman, K.J.; McClellan, R.L.; Appel, E.A.; Dorkin, J.R.; Tibbitt, M.W.; Heartlein, M.W.; DeR

BIOINSPIRED ALKENYL AMINO ALCOHOL IONIZABLE LIPID MATERIALS FOR HIGHLY POTENT IN VIVO MRNA DELIVERY

Fenton, O.S.; Kauffman, K.J.; McClellan, R.L.; Appel, E.A.; Dorkin, J.R.; Tibbitt, M.W.; Heartlein, M.W.; DeRosa, F.; Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF

INJECTABLE SELF-HEALING GLUCOSE RESPONSIVE HYDROGELS WITH PH-BASED REGULATED MECHANICAL PROPERTIES Yesilyurt, V.; Webber, M.J.; Appel, E.A.; Godwin, C., Langer, R.; Anderson, D.G.*  Advanced Materials  (2016) PDF

INJECTABLE SELF-HEALING GLUCOSE RESPONSIVE HYDROGELS WITH PH-BASED REGULATED MECHANICAL PROPERTIES

Yesilyurt, V.; Webber, M.J.; Appel, E.A.; Godwin, C., Langer, R.; Anderson, D.G.* Advanced Materials (2016) PDF

INJECTABLE AND GLUCOSE-RESPONSIVE HYDROGELS BASED ON BORONIC ACID-GLUCOSE COMPLEXATION Dong, Y.; Wang, W.; Veiseh, O.; Appel, E.A.; Xue, K.; Webber, M.J.; Tang, B.; Yang, X.-W.; Weir, G.; Langer, R.; Anderson, D.G.* Langmui

INJECTABLE AND GLUCOSE-RESPONSIVE HYDROGELS BASED ON BORONIC ACID-GLUCOSE COMPLEXATION

Dong, Y.; Wang, W.; Veiseh, O.; Appel, E.A.; Xue, K.; Webber, M.J.; Tang, B.; Yang, X.-W.; Weir, G.; Langer, R.; Anderson, D.G.* Langmuir (2016) PDF

2015

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WATER SOLUBLE, BIODEGRADABLE AMPHIPHILIC POLYMERIC NANOPARTICLES AND THE MOLECULAR ENVIRONMENT OF HYDROPHOBIC ENCAPSULATES: CONSISTENCY BETWEEN SIMULATION AND EXPERIMENT Miller, R.D.*; Yusoff, R.M.; Swope, W.C.; Rice, J.E.; Carr, A.C.; Parker,

WATER SOLUBLE, BIODEGRADABLE AMPHIPHILIC POLYMERIC NANOPARTICLES AND THE MOLECULAR ENVIRONMENT OF HYDROPHOBIC ENCAPSULATES: CONSISTENCY BETWEEN SIMULATION AND EXPERIMENT

Miller, R.D.*; Yusoff, R.M.; Swope, W.C.; Rice, J.E.; Carr, A.C.; Parker, A.J.; Sly, J.; Appel, E.A.; Nguyen, R.; Piunova, V. Polymer (2015) PDF

FORMATION OF CUCURBIT[8]URIL-BASED SUPRAMOLECULAR HYDROGEL BEADS USING DROPLET-BASED MICROFLUIDICS Xu, X.; Appel, E.A.; Liu, X.; Parker, R.; Scherman, O.A.; Abell, C.*  Biomacromolecules  (2015) PDF

FORMATION OF CUCURBIT[8]URIL-BASED SUPRAMOLECULAR HYDROGEL BEADS USING DROPLET-BASED MICROFLUIDICS

Xu, X.; Appel, E.A.; Liu, X.; Parker, R.; Scherman, O.A.; Abell, C.* Biomacromolecules (2015) PDF

EXPLOITING ELECTROSTATIC INTERACTIONS IN POLYMER-NANOPARTICLE HYDROGELS Appel, E.A.; Tibbitt, M.W.; Greer, J.M.; Fenton, O.S.; Kreuels, K.; Anderson, D.G.; Langer, R.*  ACS Macro Letters (2015) PDF

EXPLOITING ELECTROSTATIC INTERACTIONS IN POLYMER-NANOPARTICLE HYDROGELS

Appel, E.A.; Tibbitt, M.W.; Greer, J.M.; Fenton, O.S.; Kreuels, K.; Anderson, D.G.; Langer, R.* ACS Macro Letters (2015) PDF

SELF-ASSEMBLED HYDROGELS UTILISING POLYMER-NANOPARTICLE INTERACTIONS Appel, E.A.^; Tibbitt, M.W.^; Webber, M.J.; Mattix, B.A.; Veiseh, O.; Langer, R.*  Nature Communications (2015) PDF

SELF-ASSEMBLED HYDROGELS UTILISING POLYMER-NANOPARTICLE INTERACTIONS

Appel, E.A.^; Tibbitt, M.W.^; Webber, M.J.; Mattix, B.A.; Veiseh, O.; Langer, R.* Nature Communications (2015) PDF

A FACILE METHOD FOR THE STAIN-FREE VISUALIZATION OF HIERARCHICAL STRUCTURES WITH ELECTRON MICROSCOPY Williams, P.E.; Appel, E.A.; Jones, S.T.; del Barrio, J.; Lan, Y.; Scherman, O.A.*  Journal of Polymer Science Part A: Polymer C

A FACILE METHOD FOR THE STAIN-FREE VISUALIZATION OF HIERARCHICAL STRUCTURES WITH ELECTRON MICROSCOPY

Williams, P.E.; Appel, E.A.; Jones, S.T.; del Barrio, J.; Lan, Y.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2015) PDF

SYNTHESIS OF CONDUCTING POLYMER-METAL NANOPARTICLE HYBRIDS VIA RAFT POLYMERIZATION Williams, P.E.; Jones, S.T.; Walsh, Z.; Appel, E.A.; Abo-Hamed, E.K.; Scherman, O.A.*  ACS Macro Letters (2015) PDF

SYNTHESIS OF CONDUCTING POLYMER-METAL NANOPARTICLE HYBRIDS VIA RAFT POLYMERIZATION

Williams, P.E.; Jones, S.T.; Walsh, Z.; Appel, E.A.; Abo-Hamed, E.K.; Scherman, O.A.* ACS Macro Letters (2015) PDF

2014

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NON-CELL-ADHESIVE SUBSTRATES FOR PRINTING OF ARRAYED BIOMATERIALS Appel, E.A.; Larson, B.L.; Luly, K.M.; Kim, J.D.; Langer, R.*  Advanced Healthcare Materials (2014) PDF

NON-CELL-ADHESIVE SUBSTRATES FOR PRINTING OF ARRAYED BIOMATERIALS

Appel, E.A.; Larson, B.L.; Luly, K.M.; Kim, J.D.; Langer, R.* Advanced Healthcare Materials (2014) PDF

HEALABLE, STABLE AND STIFF HYDROGELS: COMBINING CONFLICTING PROPERTIES USING DYNAMIC AND SELECTIVE THREE-COMPONENT RECOGNITION WITH REINFORCING CELLULOSE NANORODS Mckee, J.^; Appel, E.A.^; Seitsonen, J.; Kontturi, E.; Scherman, O.A.*; Ikka

HEALABLE, STABLE AND STIFF HYDROGELS: COMBINING CONFLICTING PROPERTIES USING DYNAMIC AND SELECTIVE THREE-COMPONENT RECOGNITION WITH REINFORCING CELLULOSE NANORODS

Mckee, J.^; Appel, E.A.^; Seitsonen, J.; Kontturi, E.; Scherman, O.A.*; Ikkala, O.* Advanced Functional Materials (2014) PDF

THE CONTROL OF CARGO RELEASE FROM PHYSICALLY CROSSLINKED HYDROGELS BY CROSSLINK DYNAMICS Appel, E.A.; Forster, R.A.; Rowland, M.J.; Scherman, O.A.*  Biomaterials (2014) PDF

THE CONTROL OF CARGO RELEASE FROM PHYSICALLY CROSSLINKED HYDROGELS BY CROSSLINK DYNAMICS

Appel, E.A.; Forster, R.A.; Rowland, M.J.; Scherman, O.A.* Biomaterials (2014) PDF

ACTIVATION ENERGIES CONTROL MACROSCOPIC PROPERTIES OF PHYSICALLY CROSSLINKED MATERIALS Appel, E.A.; Forster, R.A.; Koutsiobas, A.; Toprakcioglu, C.; Scherman, O.A.*  Angewandte Chemie International Edition (2014) PDF

ACTIVATION ENERGIES CONTROL MACROSCOPIC PROPERTIES OF PHYSICALLY CROSSLINKED MATERIALS

Appel, E.A.; Forster, R.A.; Koutsiobas, A.; Toprakcioglu, C.; Scherman, O.A.* Angewandte Chemie International Edition (2014) PDF

GLUING GELS: A NANOPARTICLE SOLUTION Appel, E.A.* and Scherman, O.A.*  Nature Materials  (2014) PDF

GLUING GELS: A NANOPARTICLE SOLUTION

Appel, E.A.* and Scherman, O.A.* Nature Materials (2014) PDF

2013

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DYNAMICALLY CROSSLINKED MATERIALS VIA RECOGNITION OF AMINO ACIDS BY CUCURBIT[8]URIL Rowland, M.J.^; Appel, E.A.^; Coulston, R.; Scherman, O.A.*  Journal of Materials Chemistry B (2013) PDF

DYNAMICALLY CROSSLINKED MATERIALS VIA RECOGNITION OF AMINO ACIDS BY CUCURBIT[8]URIL

Rowland, M.J.^; Appel, E.A.^; Coulston, R.; Scherman, O.A.* Journal of Materials Chemistry B (2013) PDF

2012

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TRIGGERED INSULIN RELEASE STUDIES OF TRIPLY RESPONSIVE SUPRAMOLECULAR MICELLES Loh, X.J.; Tsai, M.-H.; del Barrio, J.; Appel, E.A.; Scherman, O.A.*  Polymer Chemistry  (2012) PDF

TRIGGERED INSULIN RELEASE STUDIES OF TRIPLY RESPONSIVE SUPRAMOLECULAR MICELLES

Loh, X.J.; Tsai, M.-H.; del Barrio, J.; Appel, E.A.; Scherman, O.A.* Polymer Chemistry (2012) PDF

TRIPLY TRIGGERED DOXORUBICIN RELEASE FROM SUPRAMOLECULAR NANOCONTAINERS Loh, X.J.; del Barrio, J.; Toh, P.P.C.; Lee, T.-C.; Jiao, D.; Rauwald, U.; Appel, E.A.; Scherman, O.A.*  Biomacromolecules (2012) PDF

TRIPLY TRIGGERED DOXORUBICIN RELEASE FROM SUPRAMOLECULAR NANOCONTAINERS

Loh, X.J.; del Barrio, J.; Toh, P.P.C.; Lee, T.-C.; Jiao, D.; Rauwald, U.; Appel, E.A.; Scherman, O.A.* Biomacromolecules (2012) PDF

HIGH MOLECULAR WEIGHT POLYACRYLAMIDES BY ATRP: ENABLING ADVANCEMENTS IN WATER-BASED APPLICATIONS Appel, E.A.; del Barrio, J.; Loh, X.J.; Dyson, J.; Scherman, O.A.*  Journal of Polymer Science Part A: Polymer Chemistry (2012) PDF

HIGH MOLECULAR WEIGHT POLYACRYLAMIDES BY ATRP: ENABLING ADVANCEMENTS IN WATER-BASED APPLICATIONS

Appel, E.A.; del Barrio, J.; Loh, X.J.; Dyson, J.; Scherman, O.A.* Journal of Polymer Science Part A: Polymer Chemistry (2012) PDF

BIODEGRADABLE NANOGEL STAR POLYMERS VIA ORGANOCATALYTIC ROP Appel, E.A.; Lee, V.Y.; Nguyen, T.T.; McNeil, M.; Hedrick, J.L.; Miller, R.D.*; Sly, J.*  Chemical Communications  (2012) PDF

BIODEGRADABLE NANOGEL STAR POLYMERS VIA ORGANOCATALYTIC ROP

Appel, E.A.; Lee, V.Y.; Nguyen, T.T.; McNeil, M.; Hedrick, J.L.; Miller, R.D.*; Sly, J.* Chemical Communications (2012) PDF

SUPRAMOLECULAR POLYMERIC HYDROGELS Appel, E.A.; del Barrio, J.; Loh, X.J.; Scherman, O.A.*  Chemical Society Reviews  (2012) PDF

SUPRAMOLECULAR POLYMERIC HYDROGELS

Appel, E.A.; del Barrio, J.; Loh, X.J.; Scherman, O.A.* Chemical Society Reviews (2012) PDF

ENHANCED STABILITY AND ACTIVITY OF TEMOZOLOMIDE IN PRIMARY GBM CELLS WITH CUCURBIT[n]URIL Appel, E.A.^; Rowland, M.J.^; Loh, X.J.; Heywood, R.M.; Watts, C.; Scherman, O.A.* Chemical Communications  (2012) PDF

ENHANCED STABILITY AND ACTIVITY OF TEMOZOLOMIDE IN PRIMARY GBM CELLS WITH CUCURBIT[n]URIL

Appel, E.A.^; Rowland, M.J.^; Loh, X.J.; Heywood, R.M.; Watts, C.; Scherman, O.A.* Chemical Communications (2012) PDF

SUSTAINED RELEASE OF PROTEINS FROM A HIGH-WATER-CONTENT SUPRAMOLECULAR POLYMERIC HYDROGEL Appel, E.A.; Loh, X.J.; Jones, S.T.; Dreiss, C.A.; Scherman, O.A.*  Biomaterials  (2012) PDF

SUSTAINED RELEASE OF PROTEINS FROM A HIGH-WATER-CONTENT SUPRAMOLECULAR POLYMERIC HYDROGEL

Appel, E.A.; Loh, X.J.; Jones, S.T.; Dreiss, C.A.; Scherman, O.A.* Biomaterials (2012) PDF

ULTRAHIGH-WATER-CONTENT HYDROGELS FROM RENEWABLE RESOURCES EXHIBITING MULTI-STIMULI RESPONSIVENESS Appel, E.A.; Loh, X.J.; Jones, S.T.; Biedermann, F.; Dreiss, C.A.; Scherman, O.A.* Journal of the American Chemical Society (2012) PDF

ULTRAHIGH-WATER-CONTENT HYDROGELS FROM RENEWABLE RESOURCES EXHIBITING MULTI-STIMULI RESPONSIVENESS

Appel, E.A.; Loh, X.J.; Jones, S.T.; Biedermann, F.; Dreiss, C.A.; Scherman, O.A.* Journal of the American Chemical Society (2012) PDF

METASTABLE SINGLE-CHAIN POLYMER NANOPARTICLES PREPARED BY DYNAMIC CROSSLINKING WITH NOR-SECO-CUCURBIT[10]URIL Appel, E.A.; Dyson, J.; del Barrio, J.; Isaacs, L.; Scherman, O.A.*  Chemical Science (2012) PDF

METASTABLE SINGLE-CHAIN POLYMER NANOPARTICLES PREPARED BY DYNAMIC CROSSLINKING WITH NOR-SECO-CUCURBIT[10]URIL

Appel, E.A.; Dyson, J.; del Barrio, J.; Isaacs, L.; Scherman, O.A.* Chemical Science (2012) PDF

FORMATION OF SINGLE-CHAIN POLYMER NANOPARTICLES IN WATER THROUGH HOST-GUEST INTERACTIONS Appel, E.A.; Dyson, J.; del Barrio, J.; Walsh, Z.; Scherman, O.A.*  Angewandte Chemie International Edition (2012) PDF - highlighted as a ''Hot P

FORMATION OF SINGLE-CHAIN POLYMER NANOPARTICLES IN WATER THROUGH HOST-GUEST INTERACTIONS

Appel, E.A.; Dyson, J.; del Barrio, J.; Walsh, Z.; Scherman, O.A.* Angewandte Chemie International Edition (2012) PDF
- highlighted as a ''Hot Paper'' by the editors of Angew. Chem. Int. Ed. 

2011

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POST-POLYMERIZATION MODIFICATION OF HYDROXYL-FUNCTIONALIZED POLYMERS WITH ISOCYANATES Biedermann, F.; Appel, E.A.; del Barrio, J.; Gruendling, T.; Barner-Kowollik, C.; Scherman, O.A.*  Macromolecules (2011) PDF

POST-POLYMERIZATION MODIFICATION OF HYDROXYL-FUNCTIONALIZED POLYMERS WITH ISOCYANATES

Biedermann, F.; Appel, E.A.; del Barrio, J.; Gruendling, T.; Barner-Kowollik, C.; Scherman, O.A.* Macromolecules (2011) PDF

SUPRAMOLECULAR GOLD NANOPARTICLE-POLYMER COMPOSITES FORMED IN WATER WITH CUCURBIT[8]URIL Coulston, R.J.; Jones, S.T.; Lee, T.-C.; Appel, E.A.; Scherman, O.A.*  Chemical Communications (2011) PDF

SUPRAMOLECULAR GOLD NANOPARTICLE-POLYMER COMPOSITES FORMED IN WATER WITH CUCURBIT[8]URIL

Coulston, R.J.; Jones, S.T.; Lee, T.-C.; Appel, E.A.; Scherman, O.A.* Chemical Communications (2011) PDF

2010

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SUPRAMOLECULAR CROSS-LINKED NETWORKS VIA HOST-GUEST COMPLEXATION WITH CUCURBIT[8]URIL Appel, E.A.; Biedermann, F.; Rauwald, U.; Zayed, J.M.; Scherman, O.A.*  Journal of the American Chemical Society (2010) PDF - highlighted in '' Host

SUPRAMOLECULAR CROSS-LINKED NETWORKS VIA HOST-GUEST COMPLEXATION WITH CUCURBIT[8]URIL

Appel, E.A.; Biedermann, F.; Rauwald, U.; Zayed, J.M.; Scherman, O.A.* Journal of the American Chemical Society (2010) PDF
- highlighted in ''Hosting Hydrogel Formation,'' Synfacts (2010)

2009

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HIERARCHICAL SUPERMOLECULAR STRUCTURES FOR SUSTAINED DRUG RELEASE Tan, J.P.K.; Kim, S.H.; Nederberg, F.; Appel, E.A.; Waymouth, R.M.; Zhang, Y.; Hedrick, J.L.*; Yang, Y.Y.*  Small (2009) PDF

HIERARCHICAL SUPERMOLECULAR STRUCTURES FOR SUSTAINED DRUG RELEASE

Tan, J.P.K.; Kim, S.H.; Nederberg, F.; Appel, E.A.; Waymouth, R.M.; Zhang, Y.; Hedrick, J.L.*; Yang, Y.Y.* Small (2009) PDF

SIMPLE APPROACH TO STABILIZED MICELLES EMPLOYING MIKTOARM TERPOLYMERS AND STEREOCOMPLEXES WITH APPLICATION IN PACLITAXEL DELIVERY Nederberg, F.; Appel, E.A.; Tan, J.P.K.; Kim, S.H.; Fukushima, K.; Sly, J.; Miller, R.D.; Waymouth, R. M.*; Y

SIMPLE APPROACH TO STABILIZED MICELLES EMPLOYING MIKTOARM TERPOLYMERS AND STEREOCOMPLEXES WITH APPLICATION IN PACLITAXEL DELIVERY

Nederberg, F.; Appel, E.A.; Tan, J.P.K.; Kim, S.H.; Fukushima, K.; Sly, J.; Miller, R.D.; Waymouth, R. M.*; Yang, Y. Y.*; Hedrick, J. L.* Biomacromolecules (2009) PDF